The DA2PP4L vaccine is a combination vaccine that protects your dog from many serious illnesses, the most common of which is distemper. Distemper is a viral disease that affects both the immune and neurological systems and it can be rapidly fatal. The DA2PP4L also protects from adenovirus-2, parvovirus, parainfluenza, and leptosporosis — all of which range from serious to potentially fatal to your canine.
The Bordetella vaccination is a yearly oral vaccination indicated in dogs that go to shows, are boarded, or go to obedience classes. It is used to prevent kennel cough and other upper respiratory diseases. It is transmitted by infected dogs like the common cold. Symptoms include a hacking cough and sneezing.
The Rabies vaccination is a core vaccination. It causes behavioral changes and affects the nervous system. It is transmissible to all mammals, including humans, and is fatal.